Sugar's Dark Side: How Glycolysis Fuels Cancer Beyond the 'Two-Hit' Theory

By Max Cerquetti May 12, 2024 | BRCA2 Cancer Prevention Cancer Research Diet and Cancer Genetic Mutations Glycolysis Metabolic Disorders Methylglyoxal Oncology Oncology Innovations Tumor Suppression

01. The Paradigm of Tumor Suppression Knudson's "Two-Hit" Paradigm Explained Understanding the Original "Two-Hit" HypothesisIn 1971, Alfred Knudson proposed the groundbreaking "two-hit" hypothesis to explain the development of hereditary retinoblastoma, a rare form of childhood eye cancer. According to this hypothesis, two successive genetic "hits" or mutations were necessary to...