Nutriop Longevity®·Foundational Polyphenol
Wake up your SIRT1 genes. Feel the difference.
Enhanced Absorption & Bioactivity Matrix
Not the jittery, crash-later kind. The steady, "I actually want to do things after dinner" kind. When your cells get what they need, energy isn't forced - it just happens. That's what balanced cellular function feels like. And here's a bonus: quercetin actually helps your muscles use oxygen better. Weekend warriors, you're welcome.
Here's what excited us: Quercetin isn't just making resveratrol work better (though it triples absorption). It's its own antioxidant powerhouse. Those seasonal allergies that got worse with age? Quercetin helps calm them. That post-workout inflammation that lasts for days now? Quercetin speeds recovery. Even your cells' defense against damage gets an upgrade. It's like we snuck in a second supplement for free.
Together, these two create something special. Resveratrol activates your longevity genes while quercetin shields your cells from daily damage. One rebuilds, one protects. Your cells get both renovation and security - the full cellular wellness package.
Multi-Compound Lab Verification
Delivery between:
99% pure trans-resveratrol from Japanese Knotweed, enhanced with quercetin for improved absorption. Two ingredients. One capsule. The polyphenol pairing that started it all.
In the early 1990s, scientists noticed something odd. The French ate diets rich in saturated fat — butter, cheese, foie gras — yet had relatively low rates of cardiovascular disease compared to other Western countries. They called it the French Paradox, and it set off one of the longest-running investigations in nutritional science.
The leading hypothesis? Something in red wine was providing a protective effect. That something turned out to be resveratrol — a polyphenol produced naturally by grapes, berries, and certain plants as a defence against environmental stress.
Since then, resveratrol has become one of the most-studied molecules in longevity research. Thousands of published papers have examined its mechanisms, and the picture that's emerged is compelling.
Resveratrol activates a protein called SIRT1 — sometimes called the "longevity gene" because of its role in cellular protection. When SIRT1 is active, it helps repair DNA damage, supports healthy inflammatory response, and promotes efficient cellular metabolism. It's one of a family of proteins called sirtuins that act as a kind of maintenance crew for your cells.
Resveratrol also functions as a potent antioxidant, helping neutralise free radicals that cause oxidative stress — the cumulative cellular damage that accelerates ageing.
The catch: Not all resveratrol is created equal. The molecule exists in two forms: trans-resveratrol (biologically active) and cis-resveratrol (much less active). Many supplements use a mix. Ours is 99% trans-resveratrol — the form used in published research and the form your body actually uses.
Here's something most resveratrol supplement companies don't tell you: resveratrol has a bioavailability problem.
Your body metabolises resveratrol quickly. It undergoes extensive first-pass metabolism in the gut and liver, which means a significant portion of what you swallow gets broken down before it reaches your bloodstream in its active form. This is well-documented in pharmacokinetic studies and it's the biggest limitation of standalone resveratrol supplements.
Quercetin is a flavonoid — a plant compound found in onions, apples, and berries. Research has shown that when quercetin is taken alongside resveratrol, it inhibits some of the enzymes responsible for breaking resveratrol down. The result? More trans-resveratrol reaches your bloodstream intact, and it stays active for longer.
This isn't a marketing claim — it's published biochemistry. Quercetin acts as a natural bioavailability enhancer for resveratrol. That's why we include 200mg of quercetin dihydrate (sourced from Sophora Japonica) in every capsule alongside 500mg of trans-resveratrol. It's not two supplements in one bottle. It's one formula designed so both ingredients make each other work better.
On its own, quercetin is a well-studied flavonoid with its own research base. It functions as an antioxidant, supports healthy inflammatory response, and has been studied for its potential cardiovascular benefits. When combined with resveratrol, the two compounds provide overlapping but distinct antioxidant protection — covering more ground than either one alone.
The quercetin-resveratrol synergy has been documented in peer-reviewed pharmacokinetic studies. This isn't theoretical — it's a clinically observed enhancement of bioavailability that sets this formulation apart.
We didn't add ten compounds to make the label look impressive. This formula contains two active ingredients, each at a purposeful dose, each with a specific role. That's it.
99% pure trans-form — the gold standard source. This is the biologically active form: the one that activates SIRT1, the one used in published research, the one your body utilises. Every batch independently tested via HPLC-UV.
A stable, well-absorbed form of quercetin. Primary role: enhancing resveratrol absorption by inhibiting metabolic enzymes. It also brings its own antioxidant and cardiovascular benefits. At 400mg per daily serving (2 caps) — the dose is meaningful, not token.
| Spec | Detail |
|---|---|
| Active ingredients | Trans-Resveratrol (500mg) + Quercetin Dihydrate (200mg) per capsule |
| Resveratrol source | Polygonum Cuspidatum (Japanese Knotweed) |
| Resveratrol purity | 99% trans-form (HPLC-UV verified) |
| Quercetin source | Sophora Japonica (Japanese Pagoda Tree) |
| Quercetin purity | 97.42% (HPLC-UV verified) |
| Per serving (2 caps) | 1,000mg trans-resveratrol + 400mg quercetin = 1,400mg total |
| Capsule type | Vegan pullulan (plant-based) |
| Capsules per bottle | 60 |
| Servings per bottle | 30 (at 2 capsules/day) |
| Other ingredients | None. Vegan pullulan capsule shell only. |
| Lab testing | Third-party, ISO/IEC 17025:2017 accredited (both ingredients) |
| Origin | Formulated and packaged in Switzerland |
Third-party, ISO/IEC 17025:2017 accredited — both ingredients tested individually. Every batch is independently tested to confirm 99% trans-resveratrol content. Because what's on the label should be what's in the capsule.
The research on resveratrol spans more than two decades and thousands of published papers. Quercetin has its own substantial research base. Here's what scientists are studying — and what many of our customers report.
Resveratrol is one of the most potent natural SIRT1 activators identified. When SIRT1 is active, your cells are better equipped to resist daily wear and tear — repairing DNA damage and supporting efficient cellular metabolism.
Both compounds have been studied for cardiovascular benefits. Resveratrol supports healthy blood flow and endothelial function; quercetin has been studied for healthy blood pressure and cholesterol levels. Complementary mechanisms, broad support.
Resveratrol crosses the blood-brain barrier, providing antioxidant protection directly in brain tissue. Quercetin also reaches the brain. Customers report improved mental clarity and alertness — Kay L. described feeling "sharper, more awake."
Both are potent antioxidants that neutralise free radicals and support healthy inflammatory response — addressing the oxidative stress that's a primary driver of ageing at the cellular level.
Not a stimulant. But customers report improved energy levels and faster recovery. Jan described a noticeable "booster" after adding resveratrol to his NMN stack. These are the changes that happen when your cells function more efficiently.
These benefits aren't just theoretical. Verified reviewers on Judge.me consistently report improvements in energy, mental clarity, and overall well-being — often within the first few weeks of consistent use.
Resveratrol is a protective compound — many effects happen at a cellular level you can't directly feel. But most people notice something within the first month.
Your body is absorbing the resveratrol and quercetin and beginning to build levels. Some report slightly better sleep or a subtle sense of improved wellbeing. Don't expect fireworks — the cellular machinery is warming up.
This is when early adopters start noticing something. It's rarely dramatic — more like a background upgrade. Alicia E. reported feeling good after just two weeks. Jakub K. described feeling "full of strength and energy" at the three-week mark. Subtle — a general sense of more vitality, steadier energy.
Benefits become more defined. Recovery improves. Energy feels more stable. Kay L. described being "back rowing and cycling again after 18 months" and feeling "sharper, more awake." Jan noticed a significant energy boost at about six weeks after adding resveratrol to his NMN stack.
Resveratrol's deepest benefits — SIRT1 activation, DNA protection, antioxidant defence — accumulate over months and years. This is a supplement you take not just for how you feel next month, but for who you want to be at 60, 70, and beyond.
These are real reviews from verified Nutriop Resveratrol + Quercetin customers, collected through Judge.me and Loox. Unedited. We've included the full range because transparency matters more than a highlight reel.
"I've been taking NMN for over 2 years now, and I've experienced a new level of energy after about 6 weeks. It's more like being fully awake the whole day. However, by adding Resveratrol to my supplements, this energy level has received a booster. Not only am I more awake and in the moment, even after a long day at work (and I get up at 5am), I'll be willing to do my workout at 10pm if necessary."
"Feeling more alert & energetic. Back rowing and cycling again after 18 months of not doing anything. My concentration skills have improved which has helped with piano and French classes and I just feel sharper more awake. In November I usually feel lethargic and low due to SAD but not this year."
"I've been taking resveratrol from Nutriop for about three weeks now, and I have to say I'm very satisfied. While illnesses are spreading among my friends, I continue to feel full of strength and energy. My immune system seems to be working exceptionally well."
"I have been taking Nutriop Resveratrol for only 2 weeks now. I have had no side effects and seem to feel good. Order was easy and came on time. Will be ordering again."
"An essential part of my routine now!"
"Good quality supplement. I recommend."
"Great product feel invigorated"
"Amazing product, great price, great customer service!"
"Nutriop make good quality products and the delivery's have been very quick, in the next day or two."
"Excellent product fast delivery, this is the best that I have tried."
"Excellent"
Nutriop offers three polyphenol products. They share some ingredients and mechanisms, but they're designed for different needs and budgets.
| Resveratrol + Quercetin | Resveratrol PLUS | Pterostilbene Extreme | |
|---|---|---|---|
| What's in it | 500mg trans-resveratrol + 200mg quercetin per capsule | 500mg trans-resveratrol + quercetin + fisetin + liposomal curcumin + piperine | 100mg trans-pterostilbene + 100mg organic grape seed extract |
| Total per serving (2 caps) | 1,400mg (1,000mg resveratrol + 400mg quercetin) | 1,310mg (five active compounds) | 200mg (1 capsule serving) |
| Primary mechanism | SIRT1 activation + enhanced absorption | SIRT1 + senolytic + anti-inflammatory | SIRT1 activation + ~4× better absorption than resveratrol |
| Unique advantage | Focused, clean, two-ingredient formula. The classic pairing. | Five-compound network — adds fisetin (senolytic) and liposomal curcumin | Superior bioavailability (~80% vs ~20% for resveratrol) |
| Senolytic activity? | No | Yes — fisetin targets senescent cells | No |
| Supply per bottle | 30 days (at 2 caps/day) or 60 days (at 1 cap/day) | 30 days (standard) / 15 days (full protocol) | 90 days (standard at 1/day) / 45 days (enhanced at 2/day) |
| Price | $66.00 ★ | $101.00 | $42.00 |
| Per-day cost (at standard dose) | ~$2.20/day | ~$3.37/day | ~$0.47/day |
| Best for | The classic, most-researched polyphenol pairing at a reasonable price | Comprehensive polyphenol + senolytic coverage (premium option) | Maximum absorption efficiency, lowest cost entry point |
SIRT1 activation is only half the equation. Sirtuins need NAD+ to function — without it, activating them is like hiring workers and not giving them tools. That's why the most common supplement pairing in longevity research is resveratrol + an NAD+ precursor.
SIRT1 activation meets NAD+ restoration. This is the pairing longevity researchers keep coming back to — and exactly what Jan described: adding resveratrol to NMN and feeling "a whole new level of energy."
Polyphenol protection meets multi-pathway longevity. For people who want SIRT1 activation plus CoQ10, Astaxanthin, CA-AKG, and Urolithin A in one daily protocol.
Systemic antioxidant defence meets targeted brain nutrition. Resveratrol and quercetin protect body-wide. COGNIPRIME feeds your brain the 13 specific nutrients it needs.
SIRT1 activation meets cellular recycling. Resveratrol protects from damage. Spermidine triggers autophagy to clean out damage that's already accumulated. Two complementary mechanisms.
Two stilbenes, different absorption profiles, overlapping benefits. Resveratrol has the deeper research base. Pterostilbene has ~4× better bioavailability. Together, broader SIRT1 activation coverage.
Not exactly. Early media coverage overpromised — headlines about "red wine curing ageing" were always oversimplified. Some early trials showed mixed results, leading to a backlash. But the science has matured significantly since then.
The mechanism is well-established: resveratrol activates SIRT1, and SIRT1 plays a documented role in cellular protection. Researchers now understand that dose, form (trans vs cis), and bioavailability all matter — which is exactly why we use 99% trans-resveratrol with quercetin to enhance absorption.
You'd need roughly 100–200 glasses of red wine per day to get 500mg of resveratrol. The concentration in wine is simply too low for a supplemental dose — and the alcohol would cause far more damage than the resveratrol could repair. The French Paradox was an observation about dietary patterns, not a prescription.
Purity. Grape-derived resveratrol typically contains only 5–10% trans-resveratrol — the biologically active form. Ours is extracted from Japanese Knotweed (Polygonum Cuspidatum), which yields 99% pure trans-resveratrol. You get more of the active compound per milligram, and it's the same form used in published research.
Because it's a simpler formula. This product contains two ingredients. Resveratrol PLUS contains five (adding fisetin, liposomal curcumin, and piperine). The additional ingredients — especially liposomal curcumin — add significant raw material cost. If you want the core resveratrol + quercetin pairing without the extras, this product gives you that at a lower price point.
They complement each other in a specific, well-understood way. NMN raises NAD+ levels — the fuel your cells need. Resveratrol activates SIRT1 — a protein that uses NAD+ to perform its protective functions.
Without NAD+, SIRT1 can't work efficiently. Without SIRT1 activation, NAD+ isn't being directed toward longevity-related functions as effectively. This is why resveratrol + NMN is one of the most commonly recommended pairings in longevity research.
500mg per capsule (1,000mg per daily serving of two capsules) is at the higher end of what's commonly studied. There's no universally agreed "perfect" dose, but our serving size gives you a generous amount — and you can always take one capsule daily (500mg) if you prefer a lower dose. At one capsule per day, a single bottle lasts 60 days.
Three things. First, purity: 99% trans-resveratrol from Japanese Knotweed, verified by an independent ISO-accredited lab. Many cheaper brands use grape-derived at 5–10% trans-form. Second, quercetin: it's not filler — it's a functional absorption enhancer backed by published biochemistry. Third, no fillers: our capsules contain resveratrol, quercetin, and the pullulan capsule shell. No magnesium stearate, no silicon dioxide, no rice flour, no maltodextrin.
Resveratrol and quercetin are both well-tolerated at supplemental doses. Alicia E. specifically noted "no side effects" in her review. As with any supplement, consult your doctor if you're on medication — particularly blood thinners (resveratrol may have mild anticoagulant properties) or medications metabolised by CYP enzymes (which quercetin may affect).
Try Resveratrol + Quercetin for up to three months. If you don't notice a meaningful difference — in your energy, your recovery, or how you feel day-to-day — email us for a full refund. We'll ask what you experienced so we can keep improving, but we won't make it difficult. That's the deal.
500mg resveratrol + 200mg quercetin. With or without food — absorbs well either way.
500mg resveratrol + 200mg quercetin. Consistent AM/PM dosing maintains steady levels throughout the day.
1,000mg trans-resveratrol + 400mg quercetin per day. Maximum: do not exceed 4 capsules (2,800mg) per day.
Resveratrol's effects are primarily protective and cumulative. Unlike NMN, where many people feel an energy difference within weeks, resveratrol works more quietly — activating SIRT1, providing antioxidant defence, and supporting cardiovascular health over time. Some people report improved energy and mental clarity within 2-3 weeks. The full benefits build with consistent daily use.
Every batch of Resveratrol + Quercetin is tested by MS Bioanalytical, an independent laboratory accredited to ISO/IEC 17025:2017. Both active ingredients are tested individually using HPLC-UV analysis — meaning you get a separate Certificate of Analysis for each compound. Two COAs for a two-ingredient product. That's the level of transparency we think you deserve.
99% pure trans-resveratrol. 97% pure quercetin dihydrate. Both independently tested — both COAs downloadable on this page. Formulated in Switzerland. Backed by 11 verified reviews and a 90-day money-back guarantee.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. Consult a healthcare professional before starting any supplement regimen.
