Boosting NAD+ Metabolism with NMN Supplementation: The Latest Clinical Trial Results

通过补充 NMN 促进 NAD+ 代谢:最新临床试验结果

介绍

在追求健康衰老的过程中,科学家们一直在探索各种可能减缓衰老过程并改善整体健康的化合物。 烟酰胺单核苷酸 (NMN) 是一种引起广泛关注的化合物。 NMN 是维生素 B3 的衍生物,在称为烟酰胺腺嘌呤二核苷酸 (NAD+) 的重要细胞资源的生产中发挥着至关重要的作用。 NAD+ 对于能量产生、DNA 修复和各种其他细胞功能至关重要。随着年龄的增长,我们体内的 NAD+ 水平下降,导致细胞功能下降并加速衰老过程。

最近,一项名为“ 长期补充烟酰胺单核苷酸后烟酰胺腺嘌呤二核苷酸代谢和动脉僵硬:一项随机、双盲、安慰剂对照试验”的开创性研究发表,揭示了补充 NMN 对人类的潜在益处。这篇博文旨在打破复杂的科学术语,以一种读者容易理解的方式呈现这项研究的结果。

研究设计

该研究是一项随机、双盲、安慰剂对照试验,被认为是临床研究的黄金标准。它涉及 36 名年龄在 40 岁至 65 岁之间的健康男性和女性参与者。参与者被随机分配到两组。一组接受 NMN 补充剂(125 毫克/胶囊),另一组接受安慰剂胶囊。参与者被要求每天两次饭后服用一粒胶囊,为期 12 周。

目标

该研究的主要目的是调查长期补充 NMN 对心血管疾病危险因素(包括动脉僵硬度)的影响。动脉僵化是一种与衰老相关的常见病症,也是心血管疾病的重要危险因素。

方法论

在研究开始之前,参与者接受了一系列测试以评估他们的整体健康状况。这些测试包括测量BMI(身体质量指数)、血压、血糖水平、肝功能、血脂和激素。研究人员还测量了参与者的ABI(踝臂指数)和baPWV(臂踝脉搏波速度),它们是动脉僵硬度的指标。

在研究过程中,研究人员监测了NAM(烟酰胺)、NMNNAD+的血清浓度。这些化合物在细胞能量产生和整体细胞健康中发挥着至关重要的作用

调查结果

研究结果非常有希望。研究人员发现,长期补充 NMN 会导致参与者的 NAD+ 代谢发生显着变化。更重要的是,他们观察到,与服用安慰剂的参与者相比,服用 NMN 补充剂的参与者的动脉僵硬度有所降低

这些研究结果表明,补充 NMN 可能会改善动脉健康并降低心血管疾病的风险。然而,研究人员指出,需要进一步的临床试验来证实这些益处。

这对你意味着什么?

这项研究的结果对于任何对健康老龄化感兴趣的人来说都是令人兴奋的消息。他们认为,补充 NMN 可能是改善动脉健康和降低心血管疾病风险的潜在策略,心血管疾病是全球死亡的主要原因之一。

然而,值得注意的是,虽然这项研究的结果很有希望,但还需要更多的研究来充分了解 NMN 补充剂对人类的影响。与往常一样,建议在开始任何新的补充方案之前咨询医疗保健专业人士。

副作用和安全性

任何临床试验的关键方面之一是评估安全性和潜在副作用。在这项研究中,研究人员在整个试验过程中密切关注参与者的健康状况。好消息是,研究期间没有报告严重的不良反应。 这与之前的研究一致NMN 上普遍认为它是安全且耐受性良好的。

然而,值得注意的是,虽然根据目前的证据,NMN 似乎是安全的,但每个人都是独一无二的,并且可能对补充剂有不同的反应。因此,始终建议在开始任何新的补充方案之前咨询医疗保健专业人士。

结论

对健康老龄化的追求仍在继续,NMN 似乎是这一旅程中最有前途的候选者。最新的人体试验为 NMN 补充剂的潜在益处提供了宝贵的见解,表明它可以改善动脉健康并降低心血管疾病的风险。然而,需要更多的研究来充分了解 NMN 补充剂对人体的影响。与往常一样,建议在开始任何新的补充方案之前咨询医疗保健专业人士。

最后,健康老龄化之路不仅仅是服用正确的补充剂。它还涉及保持健康的生活方式,包括均衡饮食、定期锻炼、充足的睡眠和压力管理。因此,虽然 NMN 可能成为我们抗衰老武器库中的强大工具,但这只是拼图的一小部分。

请关注我们的博客,了解健康老龄化和健康领域最新研究的更多更新。祝您长寿、健康、充实的生活!

40s and 60s Health Academic Performance Active Aging Active Lifestyle Active Living adenosine triphosphate Adoptive cell therapy Aerobic Health Age Prevention Age Reversal Age-Associated Muscle Decline Age-Defying Secrets Age-Defying Strategies Age-Defying Tips Age-related CAR-T failure Age-Related Changes Age-Related Decline Age-Related Diseases Age-Related Myths Age-related Weight Gain Age-specific Nutrition Ageless Beauty Ageless Living Ageless Memory Aging and cancer Aging and Disease Aging and Health Aging and longevity Aging and Nutrition Aging Atlas aging eggs Aging Gracefully Aging Process Aging Research Aging Supplements AI stem cells Alternative Polyadenylation Alzheimer's Alzheimer's Prevention Alzheimer's treatment Alzheimer’s disease AMP-activated protein kinase AMPK anti-aging Anti-Aging Diet Anti-Aging for the Brain Anti-Aging Lifestyle Anti-Aging Research Anti-Aging Science Anti-Aging Strategies Anti-Aging Therapies Anti-Aging Tips Anti-inflammatory diet Anti-Inflammatory Foods Anti-Inflammatory Strategies AntiAging Antioxidant Supplements Antioxidants apoptosis Arterial Stiffness Athletic Training ATP Autophagie autophagy Balanced Diet Balanced Training BCAAs Behavior Modulation Berberine Bioactive Compounds Bioavailability Biological Aging biological clocks Biological Mysteries Biomarkers Biomedical Advances Biomedical engineering Black Pepper Extract blood cell counts Blood Sugar Management blood sugar regulator Blueberries and Grapes Bone Health Brain Boosting Tips Brain Exercises Brain Fitness Brain Function Brain Function Enhancers Brain Health Brain Nutrition Brain Science Brain Supplements Brain Training Brain-Boosting Diet BRCA2 Breakthrough Treatments CaffeineProsAndCons Caloric Restriction Cancer Cancer and Inflammation Cancer Prevention Cancer Research Cancer Therapy Cancer treatment CAR-T therapy CAR-T therapy for older patients CardiacRehabilitation Cardiovascular Health CardiovascularDisease CardiovascularEffects CD38 enzyme Cellular Aging Cellular energy Cellular Growth Cellular Health Cellular health optimization Cellular metabolism Cellular Rejuvenation Cellular Renewal Cellular Senescence Cerebral Blood Flow chAge Chimeric antigen receptor Cholesterol and Cancer Cholesterol Reduction Cholesterol Synthesis Chronic Disease Prevention Chronic Diseases Chronic Inflammation ChronicInflammation ChronicStress chronological age Circadian Rhythm Clinical Trials CoffeeHealth cognition Cognitive Aging Cognitive Enhancement cognitive function Cognitive Health Cognitive Longevity Cognitive Renewal Cognitive Training Cognitive Wellness Continuous Growth coptis chinensis Cork Tree Cortex phellodendri Daily Step Count Dementia Prevention Diabetes Diabetes Management Diabetes Prevention Diabetes Risk Factors Diet and Cancer Diet Tips Dietary Choices Dietary Guidelines Dietary Moderation Benefits Dietary Supplements DietaryResearch Digestive Wellness Digital Learning Disease Prevention DNA methylation DNA Repair DNA Repair and Aging DNA Secrets DNAm Drug Delivery Drug Development Duke-NUS Discoveries eAge Educational Research Emergency Workers Fitness Emotional Wellness Endothelial dysfunction Endurance Training Energy Metabolism epigenetic age epigenetic alterations Epigenetic Clock epigenetische Alter Epigenetische Uhr Ergothioneine Ergothioneine Benefits Evergreen Health Exercise and Aging Exercise and Health Exercise and Immunity Exercise and Inflammation Exercise Physiology Exercise Research Exercise Science Exercise Tips fasting FAXDC2 Enzyme female fertility ferulic acid Fitness and Wellness Fitness in Aging Fitness Recovery Fitness Risks Fitness Tips Focus and Concentration Focus and Recall Focus Enhancement Food Science Functional Foods Functional hyperemia Future of Longevity Future of Medicine gene expression Gene Expression and Longevity Gene Therapy GeneActivity Genetic Aging Genetic Blueprint Genetic Code Genetic Mutations Genetic Research Genexpression genomic instability Genomic Technologies genomics Gerontology Research geroprotection gesundes Altern GLTD Research gluconeogenesis glucose metabolism glycogenolysis Glycolysis Golden Years Golden Years Wellness Goldthread Grape Seed Extract grey hair causes Gut Bacteria Gut Health Gut Microbiome hallmarks of aging Harvard Study Insights Healing Mechanisms Health and Fitness Health and Longevity Health and Wellness Health and Wellness Tips Health Benefits Health Innovation Health Monitoring Health Promotion Health Research Health Risks of Exercise Health Risks of Sitting Health Science Health Supplements HealthAndWellbeing Healthcare Technology Healthspan Extension healthy aging Healthy Aging Tips Healthy Eating Healthy Lifestyle Healthy Living HealthyAging HealthyLifestyle heart health Heart Health in 40s HeartDiseasePrevention HeartHealth Herbal Remedies Hericium Erinaceus Herz Gesundheit high fat ketogenic diet High-Intensity Workouts Holistic Health Holistic Wellness HolisticWellness Hormonal Balance Horvath clock Human longevity Human Trials immune system Immune System and Aging Immune System Health Immunotherapy Improving CAR-T outcomes Inflamm-aging Inflammation Inflammation Insights Inflammation Management Inflammatory Diseases Innovative medical technology Insulin Resistance Insulin/IGF-1 Signaling intercellular communication intermittent fasting keto diet ketogenic diet ketones ketones bodies Kognitive Gesundheit Krebs cycle L-Ergothioneine Life Stages and Wellness LifeExtension Lifelong Clarity Lifelong Learning Lifespan Extension Lifespan Research Lifestyle and Wellness Lifestyle Changes Lifestyle Tips LifestyleChanges Lion's Mane Liposomal NMN Liposomal Technology Liposome Benefits Liposome Manufacturing Liposomes live longer living robots Longevity longevity gene Longevity Research Longevity Secrets Longevity Supplements loss of resilience Love and Longevity matsutake MCI Medical Research Meditation Mediterranean Diet Memory Aids Memory Boosters Memory Consolidation Memory Encoding Memory Enhancement Memory Improvement Memory Mastery Memory Palace Memory Retention Memory Strategies Memory Techniques Memory Tips Memory Training Menschliche Langlebigkeit Mental Agility Mental Fitness mental health Mental Resilience Mental Vitality Mental Wellbeing Mental Wellness Metabolic Changes Metabolic Disorders Metabolic dysfunction metabolic health Metabolic optimization cancer treatment Metabolic Pathways Metabolic Pathways in Cancer Metabolic Syndrome Metabolic Syndrome Management Metabolism in Aging Metabolite Supplements methionine Methylglyoxal Microbiome Research Microcirculation Midlife Health mild cognitive impairment Mind-Body Connection Mind-Gut Connection MindBodyMedicine Mindful Aging Mindful Eating Mindful Organization Mindfulness Mindfulness and Meditation Mitochondrial Health Mitochondrial optimization Mitophagy Mnemonics Moderate vs Vigorous Exercise Modern Aging Solutions Modern Lifestyle Modern Medicine Modern Science Molecular Biology Molecular Mechanisms Molecular medicine mTor activation Multi-Omics Profiling Muscle Endurance Muscle Mass Preservation NAD+ NAD+ (nicotinamide adenine dinucleotide) NAD+ and immune function NAD+ Benefits NAD+ cancer therapy NAD+ supplementation nadh NAMPT Nanotechnology Natural Compounds Natural Elixirs Natural Health Natural Rejuvenation Natural Remedies Natural Supplements Natural Weight Solutions Nature Cancer Neural Nourishment Neurodegeneration Neurodegeneration Insights Neurodegeneration Prevention Neurodegenerative Conditions Neurodegenerative Disease Prevention Neurodegenerative diseases Neurodegenerative Disorders Neuroinflammation Neurological research Neuroplasticity neuroprotection Neurovascular Coupling Neurovascular Unit Nicotinamide adenine dinucleotide nmn NMN (nicotinamide mononucleotide) NMN Supplements NR (nicotinamide riboside) Nutraceuticals Nutriop Longevity Nutriop Longevity Benefits Nutriop Longevity Products Nutriop Longevity Supplements Nutriop Longevity® Resveratrol PLUS Nutriop Supplements Nutriop Wellness NutriopLongevity Nutriop® Life Nutrition Nutrition for Seniors Nutrition Research Nutritional Guidance Nutritional Science Nutritional Strategies Nutritional Supplements Nutritional Support Omega-3 Fatty Acids Oncology Oncology Innovations oocyte quality Optimal Step Count Oral Health Oxford Academic Study Oxidative stress Oxygen Efficiency P16ink4a Parkinson's therapy Personal Transformation Personalized Exercise Plans Personalized Health Strategies Personalized Medicine Personalized Nutrition Pharmaceutical Development Phellodendron Physical Activity Physical Activity and Brain Phytoalexins Piperine Plant Metabolites Plant-based compounds Plant-Based Diet Polygenic Risk Score (PRS) Positive Thinking Premium supplements Preventative Strategies Preventive Health Preventive Healthcare Probiotics Processed Foods Protein aggregation pterostilbene Quercetin Radiant Health Recall Enhancement Reducing Sitting Time Regenerative Medicine Relationships and Health RelaxationTechniques Reproductive Aging Resilience Resilience Techniques Resveratrol rhizoma coptis chinensis rice bran RING-Bait SASP Science Science of Aging Science-backed supplementation Scientific Advancements Scientific Breakthrough Sedentary Behavior Sedentary Lifestyle Self-Improvement Senior Fitness Senior Health Senior Wellness Senior Wellness Strategies Single-Cell RNA Sequencing SIRT1 sirtuins Sleep and Cognition Sleep and Health Sleep and Metabolism sleep cycles sleep duration Sleep Research sleep stages Spermidin spermidine Step Count Benefits Stoffwechselgesundheit Stress and Weight Stress Management StressAndAging StressManagement StressReduction Student Health Supplement Benefits Supplements Swiss cancer research breakthrough T cell exhaustion Targeted Therapies Targeted Therapy Tauopathy Telomeres Timeless Living Timeless Vitality Transcriptomics Tricarboxylic acid cycle Tricholoma matsutake Tumor Suppression Type 2 Diabetes Prevention University of Lausanne research Urolithin A Vibrant Aging Vigorous Exercise Vitality VO2 Max Fitness Walking for Health Weight Loss for Elderly Weight Management Weizenkeimextrakt Wellness Wellness and Vitality Wellness in Retirement Wellness Journey Wellness Strategies Wellness Tips wheat germ extract Whole Foods Whole Grains Wnt Signaling Wnt Signaling Pathway Workout Safety xenobots yoga Youthful Vitality Zelluläre Seneszenz
Back to blog

1 comment

I like Nutriop Longeveti

Rory

Leave a comment

Please note, comments need to be approved before they are published.