A Different Kind of Magic Mushroom - How Ergothioneine Can Protect Your Brain

另一种神奇蘑菇——麦角硫因如何保护您的大脑

寻找有效的化合物来保护人类大脑免受认知能力下降的破坏,包括决策受损、无法集中注意力、记忆丧失、精神错乱,甚至全面的痴呆症,这一点从未如此紧迫。根据亚特兰大疾病控制中心的数据,美国有1600 万人患有认知障碍。其中510万人患有阿尔茨海默氏症,预计到2050年这一数字将攀升至令人震惊的1320万强>。

 

Alzheimer's disease in US - quick facts

 

全球有 5000 万人患有阿尔茨海默氏症,如果没有突破,这个已经令人震惊的数字可能到 2050 年将超过 1.52 亿

Alzheimer's disease Global Increase by 2050


蘑菇是大脑保护化合物的来源

使用蘑菇影响大脑功能无论如何都不是什么新鲜事,因此研究人员转向真菌王国寻找可以保护大脑免受疾病侵害的化合物也就不足为奇了。大约 1500 年来,土著人民一直使用有意识地改变裸盖菇素“神奇”蘑菇来改善福祉,这一点从早于玛雅人的文化开始。在过去的十年中,约翰·霍普金斯大学牵头的研究表明,裸盖菇素对重度抑郁症患者以及减少癌症患者的焦虑具有显着效果。 

portabellas蓝牡蛎大喇叭这样的蘑菇现在可以在杂货店和农贸市场中常见,并且已经成为它们自己的一员。它是健康饮食的一部分,为许多菜肴增添肉味,也是 B 族维生素和矿物质的良好来源。但也许最有趣的是蘑菇中发现的其他化合物——多酚、类胡萝卜素、吲哚和多糖,它们虽然没有营养价值,但具有抗炎抗氧化和甚至还有抗癌功效。事实上,一些蘑菇,如灵芝、冬虫夏草、白桦茸等,是专门因其药用特性而种植的。 

其中一种蘑菇,狮鬃菇,因其烹饪吸引力和作为认知保护剂的承诺而闻名。 松茸蘑菇在北美不太出名,但在日本被视为美味佳肴,因其味道而备受推崇,也被日本贵族作为特殊礼物赠送作为皇室成员,象征着长寿、生育和幸福。 


麦角硫因 - 一种有效的蘑菇脑保护剂 

两种蘑菇都含有麦角硫因(即“er-go-THIGH-oh-neen”),这是一种水溶性药用生物活性氨基酸,能够进入组织通过人体内天然存在的特定分子转运蛋白对大脑进行运输,具有有效的神经保护作用。麦角硫因仅在非酵母真菌和一些细菌中合成。植物通过土壤中的微生物产生麦角硫因,通过根部吸收麦角硫因,而人类和动物则必须通过饮食获取麦角硫因。尽管其他食物,包括肝脏、红豆、黑豆和燕麦麸都含有麦角硫因,但蘑菇仍然是人类的主要来源。


Facts and Health Benefits of Mushroom Nutrients
麦角硫因可以通过多种方式保护您的大脑。同样重要的是要了解麦角硫因还可以保护其他身体组织和系统以及大脑,并且它在包括慢性炎症在内的多种疾病中具有很大的治疗作用疾病、眼睛疾病肾脏疾病心血管疾病紫外线损伤神经损伤,甚至癌症以及细胞衰老

 

 Nutriop Longevity ERGO-SUPREME Health Benefits


麦角硫因具有广泛的抗炎和抗氧化作用,并且似乎与其他抗氧化剂一起保护线粒体免受氧化应激,从而增强线粒体功能。它也是一种清除化合物,通过中和细胞过氧化氢的有害作用,保护神经元免受 β-淀粉样蛋白诱导的细胞毒性。 麦角硫因还促进神经元干细胞的分化,这对于中枢神经系统的发育和维护至关重要。


Anti Inflammatory and Antioxidant Biology of L-Ergothioneine

 

此外,该化合物还可以阻止对 DNA 以及蛋白质的损伤,减少神经炎症,减少细胞应激,增加细胞保护蛋白的表达,增加脂氧素的水平,它们是由外周血细胞产生的天然抗炎分子。麦角硫因还具有抗衰老剂的作用,这意味着它可以破坏随着衰老而在组织中积累的老化细胞,并可能减缓衰老的进展与年龄相关的疾病和状况。

 

补充麦角硫因是关键

因此,鉴于这些多重保护作用,不难预测狮鬃松茸蘑菇的强大药用效果,因为这些蘑菇的维生素E含量相对较高。 麦角硫因狮鬃长期以来因其神经保护特性而闻名,并用于预防与年龄相关的神经退行性疾病,而松茸蘑菇因其抗衰老作用而备受推崇。衰老特性,以及它降低血压和增强神经干细胞增殖的能力。

但要获得最大的治疗效果,每天必须吃十几颗甚至更多的蘑菇!新鲜的狮鬃蘑菇,尤其是松茸蘑菇往往很难找到,而且价格昂贵,并且无法保证麦角硫因的含量> 在每个蘑菇中,因此您无法知道自己是否摄入了足够的量。补充确实是日复一日获得一致、浓缩剂量的麦角硫因的唯一方法

 

另外,与通过饮食获取的许多其他化合物类似,麦角硫因的水平随着年龄以及各种疾病的发作而下降。低水平的麦角硫因轻度认知障碍以及痴呆有关,极低的水平似乎与疾病的严重程度相对应。

 

Nutriop® 的方法

在 Nutriop® Longevity,我们立即认识到麦角硫因的巨大益处,也了解大多数人在寻找质量麦角硫因时面临的挑战他们可以信任的产品,更不用说购买足够的含有新鲜蘑菇的麦角硫因来满足他们的日常需求。因此,我们开始进行自己的详细研究,并为我们的客户制定最佳生物利用度最高麦角硫因补充剂。 

 

毫无疑问,并非所有麦角硫因补充剂都是相同的。我们仅使用最高品质的99%生物发酵松茸蘑菇(又名松茸)和狮鬃菇提取物蘑菇(又名猴头菇)作为我们新型先进L-麦角硫因配方生物发酵Nutriop® Ergo-Supreme的基础。我们还添加了所有天然阿魏酸,它是从米糠中提取的,它本身就是一种有效的抗氧化剂。此外,阿魏酸还可以减少氧化应激并改善线粒体生物合成。这种以正确比例组合的组合可以提高我们配方的功效,使其更加强大

大多数其他补充剂仅含有约 5 毫克麦角硫因,而我们的补充剂含有完整 10 毫克麦角硫因加上250 毫克 每剂量阿魏酸,为您提供两倍神经保护效力,而您只需支付完整 30 天的费用的一小部分供应。我们建议每天服用一到两次 Ergo-Supreme 胶囊,以获得最大功效,并且该配方可以与食物一起服用或单独服用。

 

您可以在此处找到有关我们的高效天然发酵麦角硫因补充剂的更多信息。使用Bio Fermented Nutriop® Ergo-Supreme补充麦角硫因将帮助您轻松利用这种强效配方的神经保护、抗炎和线粒体增强作用。 

 

那有多神奇?!!

 

 

参考:

 

1. Lam-Sidun D,Peters KM,Borradaile NM。蘑菇衍生药物?临床前研究表明麦角硫因对心脏代谢健康具有潜在益处。国际分子科学杂志。 2021 年 3 月 23 日;22(6):3246。 doi:10.3390/ijms22063246。电话号码:33806754; PMCID:PMC8004618。

2. Cheah IK,Halliwell B. 麦角硫因,最新进展。氧化还原生物。 2021 年 6 月;42:101868。 doi:10.1016/j.redox.2021.101868。 Epub 2021 年 1 月 26 日。PMID:33558182; PMCID:PMC8113028。

3. 格洛丽亚·A·马丁内斯·梅迪纳、莫妮卡·L·查韦斯·冈萨雷斯、迪帕克·库马尔·维尔马、L·阿雷利·普拉多·巴拉甘、何塞·L·马丁内斯·埃尔南德斯、阿德里安娜·C·弗洛雷斯·加列戈斯、曼塔·塔库尔、普雷姆·普拉卡什·斯里瓦斯塔夫、克里斯托瓦尔·N阿吉拉尔,蘑菇中的生物功能成分,健康机会:麦角硫氨酸和 huitlacohe 作为最新趋势,功能食品杂志,

4. Perez-Ternero C、Werner CM、Nickel AG、Herrera MD、Motilva MJ、Böhm M、Alvarez de Sotomayor M、Laufs U。阿魏酸是米糠的一种生物活性成分,可改善小鼠的氧化应激以及线粒体生物合成和动力学以及人类单核细胞。 J 营养生物化学。 2017 年 10 月;48:51-61。 doi:10.1016/j.jnutbio.2017.06.011。电子版 2017 年 6 月 24 日。PMID:28759787。

5. Wu LY、Cheah IK、Chong JR、Chai YL、Tan JY、Hilal S、Vrooman H、Chen CP、Halliwell B、Lai MKP。低血浆麦角硫因水平与痴呆症中的神经退行性变和脑血管疾病有关。自由基生物医学。 2021 年 12 月;177:201-211。 doi:10.1016/j.freeradbiomed.2021.10.019。 Epub 2021 年 10 月 19 日。PMID:34673145。

6. 保罗·BD,斯奈德·SH。不寻常的氨基酸 L-麦角硫因是一种生理细胞保护剂。细胞死亡不同。 2010 年 7 月;17(7):1134-40。 doi:10.1038/cdd.2009.163。 Epub 2009 年 11 月 13 日。PMID:19911007; PMCID:PMC2885499。

7. Smith E、Ottosson F、Hellstrand S、Ericson U、Orho-Melander M、Fernandez C、Melander O。麦角硫因与降低死亡率和心血管疾病风险相关。心。 2020 年 5 月;106(9):691-697。 doi:10.1136/heartjnl-2019-315485。 Epub 2019 年 10 月 31 日。PMID:31672783; PMCID:PMC7229907。

8. Halliwell B,Cheah IK,Drum CL。麦角硫因,一种保护受损组织的适应性抗氧化剂?一个假设。生物化学生物物理学研究中心。 2016 年 2 月 5 日;470(2):245-250。 doi:10.1016/j.bbrc.2015.12.124。 Epub 2016 年 1 月 6 日。PMID:26772879。

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